Blar i NTNU Open på forfatter "Kastnes, Martin Haugrud"

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    • FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells 

      Quist-Løkken, Ingrid; Andersson-Rusch, Clara Leticia; Kastnes, Martin Haugrud; Jürgen Markus Kolos, , Jürgen Markus; Jatzlau, Jerome; Hella, Hanne; Olsen, Oddrun Elise; Sundan, Anders; Knaus, Petra; Hausch, Felix; Holien, Toril (Journal article; Peer reviewed, 2023)
      Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ...

    • IL-32 is induced by activation of toll-like receptors in multiple myeloma cells 

      Aass, Kristin Roseth; Tryggestad, Synne Stokke; Mjelle, Robin; Kastnes, Martin Haugrud; Nedal, Tonje Marie Vikene; Misund, Kristine; Standal, Therese (Peer reviewed; Journal article, 2023)
      Multiple myeloma (MM) is a hematological cancer characterized by accumulation of malignant plasma cells in the bone marrow. The patients are immune suppressed and suffer from recurrent and chronic infections. Interleukin-32 ...

    • Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells 

      Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)
      Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ...

    • The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes 

      Kastnes, Martin Haugrud; Aass, Kristin Roseth; Bouma, Siri Anshushaug; Årseth, Charlotte; Zahoor, Muhammad; Yurchenko, Mariya; Standal, Therese (Peer reviewed; Journal article, 2023)
      IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less ...

    • Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells 

      Kastnes, Martin Haugrud (Master thesis, 2019)
      Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ...